If $D \subseteq \mathbb{R}^n$ contains an isolated point then $D$ is not open.
Let $D \subseteq \mathbb{R}^n$ and $a \in D$. If $a$ is a limit point of $D$ then there is some $\epsilon > 0$ such that $B_{\epsilon}(a) \subseteq D$.
For the first, by definition of isolated point, it must be in $D$ but not be a limit point of $D$. I have a feeling if $D = \mathbb{R}^n$ this could be a counter example, as it is a clopen set.
For the second, the consequent is the definition of open if I'm not mistaken, but I'm not sure how this relates to $a$ being a limit point of $D$.
Any help would be appreciated?