The Big Omega notation
The definition of the Big Omega $\Omega$ notation may cause confusion. Quoting Wikipedia:
Unfortunately, there are two widespread and incompatible definitions of the statement
$$f(x)=\Omega(g(x))\quad (x\rightarrow a),$$
where $a$ is some real number, $∞$, or $−∞$, where $f$ and $g$ are real functions defined in a neighbourhood of $a$, and where $g$ is positive in this neighbourhood.
The first one (chronologically) is used in analytic number theory, and the other one in computational complexity theory. When the two subjects meet, this situation is bound to generate confusion.
The Hardy–Littlewood definition
In 1914 Godfrey Harold Hardy and John Edensor Littlewood introduced the new symbol $\Omega$, which is defined as follows
$$f(x)=\Omega(g(x))\ (x\rightarrow\infty)\;\iff\;\limsup_{x \to \infty} \left|\frac{f(x)}{g(x)}\right|> 0$$
The Knuth definition
In 1976 Donald Knuth published a paper to justify his use of the $\Omega$-symbol to describe a stronger property. Knuth wrote: "For all the applications I have seen so far in computer science, a stronger requirement ... is much more appropriate". He defined $f(x)=\Omega(g(x))\Leftrightarrow g(x)=O(f(x))$, in other words
$$f(x)=\Omega(g(x))\ (x\rightarrow\infty)\;\iff\;\liminf_{x \to \infty} \left|\frac{f(x)}{g(x)}\right|> 0.$$
Difference between the Big O notation and the Big Omega notation
Since you stated that this exercise is an assignment in algorithms we will use the Knuth definition of $\Omega$. Let's look at the definitions again:
$$f=O(g) \iff \limsup_{x \to \infty} \left|\frac{f(x)}{g(x)}\right| < \infty, \qquad f=\Omega(g)\;\iff\;\liminf_{x \to \infty} \left|\frac{f(x)}{g(x)}\right|> 0$$
We have three major differences here.
Big $O$ is defined as a limit superior, whereas Big $\Omega$ is defined as a limit inferior.
The limit in the Big $O$ definition can be equal to zero, whereas the limit in the $\Omega$ definition has to be strictly greater than zero.
The limit in the $\Omega$ notation is allowed to go to $+\infty$.
So if $f= O(g)$, $|f|$ is asymptotically bounded above by $g$ and if $f=\Omega(g)$, $\lvert f\rvert$ is asymptotically bounded below by $g$.
If we look at the definition with quantifiers, we can also see how these definitions differ,
$$
\begin{align}
f&=O(g) \iff \exists\ c > 0\ \exists\ x_0 > 0\ \forall\ x > x_0: |f(x)| \le c\cdot|g(x)|,\\ \qquad f&=\Omega(g) \iff \exists\ c > 0\ \exists\ x_0 > 0\ \forall\ x > x_0: c\cdot \lvert g(x)\rvert\le|f(x)|.
\end{align}
$$
The limit and l'hopital
Let's look at the limit first. By l'hopital the solution is indeed $1$,
$$\lim\limits_{n\to\infty} \frac{n+\pi}{n-e^{2021}}= \lim\limits_{n\to\infty} \frac{\frac{\mathrm{d}}{\mathrm{d}n}(n+\pi)}{\frac{\mathrm{d}}{\mathrm{d}n}(n-e^{2021})} = \frac{1}{1} = 1.$$
One important condition which has to be satisfied if applying l'hopitals rule on $\lim_{x\to c}f(x)/g(x)$ is that $\lim_{x\to c}f'(x)/g'(x)$ must exist. From this it follows that you cannot apply l'hopital on $1/1$, since $\frac{\mathrm{d}}{\mathrm{d}n}(1)/\frac{\mathrm{d}}{\mathrm{d}n}(1)=0/0$ does not exist.
Now we can safely state that
$$n+\pi=\Omega(n-e^{2021})$$
and that
$$n+\pi \neq o(n-e^{2021}).$$
Here $\neq$ is being used loosely. Remark: By definition, if a function is in $\Omega$ it cannot be in $o$.
We may also say that $n+\pi = O(n-e^{2021})$ and the sharper statement $n+\pi \sim n-e^{2021}$, which is equivalent to the limit you evaluated earlier.