Original question: "For example if you have the quadric $Q=Z(X^2_0+X^2_1+X^2_2)$
Which lives in the three dimensional projective space. Can anybody help me? :)"
Answer: If you view $C:=V(x^2+y^2+z^2)\subseteq \mathbb{P}^2_k$ and consider $D(z)\cap C :=V((x/z)^2+(y/z)^2+1):=V(u^2+v^2+1)$ with $f:=u^2+v^2+1$, you find that the jacobian criterion proves ($char(k) \neq 2$) that $C\cap D(z)$ is regular. The following holds:
$$\partial f_u=2u, \partial f_v=2v$$
and there is no point $p\in C$ with $\partial f_v(p)=\partial f_u(p)=0$. Similar for $D(x),D(y)$. Hence the curve $C$ is regular in characteristic $\neq 2$. In characteristic $2$ you may write
$$x^2+y^2+z^2=(x+y+z)^2$$
hence the polynomial $f:=(x+y+z)^2$ is non-reduced and hence the curve $C:=V(f)$ is non-reduced and not regular.
In general if $X:=Proj(k[x_0,..,x_n]/I) \subseteq \mathbb{P}^n_k$ is a projective scheme defined by the homogeneous ideal $I:=(f_1,..,f_m)$ you get an affine open cover $U_i:=D(x_i)\cap X \subseteq X$ where $U_i=Spec(A_i)$ is an affine variety on the form $A_i=k[y_1,..,y_n]/J_i$. You may use the jacobian criterion to the ring $A_i$ and a set of generators of the ideal $J_i$.
Example: In your example of a quadric $Q:=x_0^2+\cdots +x_r^2$ you get on each open affine scheme $U_i$ a hypersurface $f_i \in k[y_1,..,y_n]$ and you must use the jacobi criterion to the polynomial $f_i$ to check non-singularity, similar to my example given above. It is a good exercise to generalize my calculation to more variables.
t explained why one can use the affine cone :( Thats the explanation I still need... – Koalalover Jul 29 '21 at 10:16