Rewriting the expression, foiling it out, and using linearity of expectations:
\begin{align}
E[AB \cdot CD] &= E[(10 \cdot A + B) \cdot (10 \cdot C + D)] \\
&= E[100 \cdot A \cdot C + 10 \cdot A \cdot D + 10 \cdot B \cdot C + B \cdot D] \\
&= 100 \cdot E[A \cdot C] + 10 \cdot E[A \cdot D] + 10 \cdot D[B \cdot C] + E[B \cdot D]
\end{align}
Note by symmetry that all of these expectations are equal to each other, therefore, adding up the coefficients:
$$E[AB \cdot CD] = 121 \cdot E[A \cdot C]$$
Yes, there are 12 different equally likely permutations for the values of $A$ and $C$. However, multiplication doesn't depend on order, so we can just look at the six combinations instead. The average of the six equally likely combinations is:
$$E[A \cdot C] = \frac{1\cdot 2 + 1 \cdot 3 + 1\cdot 4 + 2\cdot 3 + 2\cdot 4 + 3\cdot 4}{6} = \frac{35}{6}$$
Thus, the final answer is:
$$E[AB \cdot CD] = \frac{121 \cdot 35}{6}$$