Following the spirit of this question, I developed a program to check how many numbers made of permutations without repetition of the first consecutive positive integers were prime numbers. Let us call $S(n)$ the set of numbers made of all the permutations of the first $n$ positive integers. For instance, $S(3)=\{123,132,213,231,312,321\}$.
For similar reasons to the ones exposed in this partial answer I gave to the question cited, $S(n)$ contains no prime number for $n\neq 3k+1$, as the sum of digits of any permutation in some set $S(3k)$ is divisible by $3$ (and by divisibility criteria it follows that such permutation is divisible by $3$ too), and this in turn implies divisibility by $3$ of any permutation in some set $S(3k-1)$.
Therefore, I have focused only on the sets $S(3k+1)$. Let us call $P(n)$ the subset made of permutations of $S(n)$ that are prime numbers. I found that $$|P(4)|=4$$ $$|P(7)|=534$$ $$|P(10)|=2808500$$
I have not been able to calculate the cardinality of more sets $P(3k+1)$, as my computer runs out of memory for bigger sets (it has to check $(3k+1)!$ numbers!). However, I have come up to the following
Conjecture
Let $D(3k+1)$ count the number of digits of any permutation of some set $P(3k+1)$. Then,
$$\lim_{k\to \infty}\frac{(D(3k+1)-1)!}{|P(3k+1)|}=1$$
It is a "bold" conjecture, as I only have three data to support it: $$\frac{(D(4)-1)!}{|P(4)|}=1.5$$ $$\frac{(D(7)-1)!}{|P(7)|}=1.34$$ $$\frac{(D(10)-1)!}{|P(10)|}=1.292$$
It would be great (i) to have more data that helps to strengthen (or discard) the conjecture, (ii) to have an insight on the reasonability (or not) of it, and (iii) of course, if there is some literature on the subject, more than glad to hear of it!
Thanks in advance!
Also you should check whether your conjecture is consistent with Prime Number Theorem or the Cramer random model [https://en.wikipedia.org/wiki/Cram%C3%A9r%27s_conjecture#:~:text=Terence%20Tao.%5B5%5D-,Heuristic%20justification,-%5Bedit%5D]. If it's not, then that would be reason for skepticism.
– user34722 Dec 07 '21 at 17:44