From a programming perspective, the difference between vectors of integers and vectors of floating point numbers is very much the same as the difference between integers and floating point numbers.
Integers are very easy for computers to handle; numbers involving decimals less so. If you were to dig under the hood of your favorite programming language, you'd find that even the most basic operations (addition/subtraction/multiplication/etc.) are handled differently for the two types - they are even stored differently in memory.
In a theoretical context, there is still a massive amount of difference between vectors of integers and vectors of reals. For instance, vectors of integers don't form a vector space - because they are not closed under scalar multiplication by elements in $\mathbb{R}$ (or $\mathbb{C}$). Further, there is a very real sense in which there are "fewer" vectors of integers: even though bouth $\mathbb{Z}$ and $\mathbb{R}$ are infinite, $\mathbb{Z}$ is countably infinite whereas $\mathbb{R}$ is uncountably infinite. The same can be said of $\mathbb{Z}^n$ vs $\mathbb{R}^n$.