Notice that we can split the integral up into
\begin{align*}
\int_{x^3}^{e^{2x}}\frac{\sin(3y)}{\sqrt{y^2+\cos(3y)+1}}\,\mathrm{d}y
&=\int_a^{e^{2x}}\frac{\sin(3y)}{\sqrt{y^2+\cos(3y)+1}}\,\mathrm{d}y+\int_{x^3}^a\frac{\sin(3y)}{\sqrt{y^2+\cos(3y)+1}}\,\mathrm{d}y \\
&=\int_a^{e^{2x}}\frac{\sin(3y)}{\sqrt{y^2+\cos(3y)+1}}\,\mathrm{d}y-\int_a^{x^3}\frac{\sin(3y)}{\sqrt{y^2+\cos(3y)+1}}\,\mathrm{d}y
\end{align*}
for some $a\in\mathbb{R}$. Applying the chain rule and the fundamental theorem of calculus we thus get that
\begin{align*}
\frac{\mathrm{d}}{\mathrm{d}x}\left(\int_{x^3}^{e^{2x}}\frac{\sin(3y)}{\sqrt{y^2+\cos(3y)+1}}\,\mathrm{d}y\right)
&=\frac{\mathrm{d}}{\mathrm{d}x}\left(\int_a^{e^{2x}}\frac{\sin(3y)}{\sqrt{y^2+\cos(3y)+1}}\,\mathrm{d}y\right)-\frac{\mathrm{d}}{\mathrm{d}x}\left(\int_a^{x^3}\frac{\sin(3y)}{\sqrt{y^2+\cos(3y)+1}}\,\mathrm{d}y\right) \\
&=\frac{2e^{2x}\sin(3e^{2x})}{\sqrt{e^{4x}+\cos(3e^{2x})+1}}-\frac{3x^2\sin(3x^3)}{\sqrt{x^6+\cos(3x^3)+1}}
\end{align*}