You could consider $F(u,v,w)=u^{v^w}$ and composed with $u(x)=v(x)=w(x)=x$ and use the multivariate chain rule. You want $\frac{d}{dx}\left(\frac{d}{dx}F\circ(u,v,w)\right)$.
$$\begin{align}
\frac{d}{dx}\left(\frac{d}{dx}F\circ(u,v,w)\right)
&=\frac{d}{dx}\left(\frac{\partial F}{\partial u}\frac{d u}{d x}+\frac{\partial F}{\partial v}\frac{d v}{d x}+\frac{\partial F}{\partial w}\frac{d w}{d x}\right)\\
&=\frac{d}{dx}\left(\frac{\partial F}{\partial u}+\frac{\partial F}{\partial v}+\frac{\partial F}{\partial w}\right)\\
&=\frac{d}{dx}\left(\frac{\partial F}{\partial u}\right)+\frac{d}{dx}\left(\frac{\partial F}{\partial v}\right)+\frac{d}{dx}\left(\frac{\partial F}{\partial w}\right)\\
&=\sum_{h=u,v,w}\sum_{k=u,v,w}\frac{\partial}{\partial h}\left(\frac{\partial F}{\partial k}\right)\frac{dh}{dx}\\
&=\sum_{h=u,v,w}\sum_{k=u,v,w}\frac{\partial}{\partial h}\left(\frac{\partial F}{\partial k}\right)\\
\end{align}$$
This is a sum over 9 terms. Let's explicitly find $F$'s first derivatives:
$$\begin{align}
\frac{\partial F}{\partial u}&=v^wu^{v^w-1}&
\frac{\partial F}{\partial v}&=u^{v^w}\ln(u)wv^{w-1}&
\frac{\partial F}{\partial w}&=u^{v^w}\ln(u)v^{w}\ln(v)
\end{align}$$
Now then:
$$\begin{align}
&\frac{d}{dx}\left(\frac{d}{dx}F\circ(u,v,w)\right)\\
&=\sum_{h=u,v,w}\frac{\partial}{\partial h}\left(v^wu^{v^w-1}+u^{v^w}\ln(u)wv^{w-1}+u^{v^w}\ln(u)v^{w}\ln(v)\right)\\
&=\sum_{h=u,v,w}\frac{\partial}{\partial h}\left[F(u,v,w)\cdot v^{w-1}\left(\frac{v}{u}+\ln(u)\left[w+v\ln(v)\right]\right)\right]\\
&\text{Three times, use the product rule over three factors.}\\
&\text{Divide out $u^{v^w}$ and $v^{w-1}$ as you go, for simplicity.}\\
\frac{1}{u^{v^w}v^{w-1}}\frac{d^2F}{dx^2}&= u^{-1}v^{w}\left(\frac{v}{u}+\ln(u)\left[w+v\ln(v)\right]\right) + \left(-\frac{v}{u^2}+\frac{1}{u}\left[w+v\ln(v)\right]\right)\\
&\\
&{}+\ln(u)wv^{w-1}\left(\frac{v}{u}+\ln(u)\left[w+v\ln(v)\right]\right)\\
&{}+(w-1)v^{-1}\left(\frac{v}{u}+\ln(u)\left[w+v\ln(v)\right]\right)+\left(\frac{1}{u}+\ln(u)\left[\ln(v)+1\right]\right)\\
&\\
&{}+\ln(u)v^{w}\ln(v)\left(\frac{v}{u}+\ln(u)\left[w+v\ln(v)\right]\right)\\
&{}+\ln(v)\left(\frac{v}{u}+\ln(u)\left[w+v\ln(v)\right]\right)+\ln(u)
\end{align}$$
Well, is it worth continuing? Just as painful as what you were first considering? But you could replace $u,v,w$ with $x$ and simplify.