Hints:
First, recall the gist and definition of big $O$ notation given by your syllabus. The gist is that we write $f(n)=O(g(n))$ if, as $n$ increases, $g$ grows faster than, or as fast as, $f$. It should be fairly clear which of $2^n$ and $n^2$ grows faster. The typical full definition is that for two real-valued functions of real variables $f$ and $g$, if all sufficiently large arguments $n>n_0$ have $|f(n)|$ equal to or bounded above by $Mg(n)$ for some positive real constant $M$, then we write that $f(n)=O(g(n))$.
So, in this case, we are asking whether it is possible to construct the bound $2^n\le Mn^2$ for all $n>n_0$ and some $M>0$.
Then, manipulate the inequality $2^n\le Mn^2$ with the aim of deriving a contradiction. One way to do this might be as $\displaystyle \frac{Mn^{2}}{2^{n}}-1\ge0$ and then expanding $2^n$ in order to compare it with polynomials.