What is infinitary λ-calculus?
In one sentence: it is λ-calculus with (possibly) infinite(ly deep) terms, and (possibly) infinite β-reductions. Notice that finite terms and reductions are also infinitary ones!
If you have done a bit of λ-calculus, you probably already know some infinitary λ-terms: the Böhm trees, a notion on infinite normal form introduced by Barendregt. For instance, the Böhm tree of any fix-point combinator $Y$ is $\lambda f.fff\dots$ (an infinite sequence of $f$). The infinitary λ-calculus formalizes this idea that $Y \longrightarrow_{\beta}^{\infty} \lambda f.fff\dots$.
It was first defined in Kennaway et al. (1997) using a topological definition: infinite terms are limits of Cauchy sequences of finite terms, and the infinitary reduction is defined by sequences of β-reductions enjoying a strong convergence property. Later, it was reformulated into an elegant coinductive definition (Endrullis and Polonsky 2013). If you want a survey on the subject, see Chapter 6 of the recent Barendregt-Manzonetto Satellite.
(I keep this answer very short since I don't know exactly what you are expecting, feel free to add comments so that I can precise my answer.)
How is it different compared to conventional lambda calculus? What are the benefits of infinitary lambda calculus?
Normalization. — Still, the infinitary λ-calculus is not normalizing; for instance, $\Omega$ has no infinitary normal form. But there are more normalizable terms than in the finitary setting (e.g. $Y$).
Confluence. — The confluence property is broken. However, introducing a variant of the β-reduction (the β$\bot$-reduction, which reduces all “problematic” terms to a constant $\bot$ in one step) is sufficient to retrieve confluence. (There is a precise definition of “problematic”, see the literature about meaningless sets of λ-terms. The precise result is: the infinitary β-reduction modulo some meaningless set is confluent, see Czajka 2020.)
This variant is also normalizing: in the “general” infinitary λ-calculus, for any term $M$ we have $M \longrightarrow_{\beta\bot}^{\infty} \mathrm{BerT}(M)$ its Berarducci tree (Berarducci 1996, a refinement of Böhm trees), which is in normal form. If you're interested in Böhm trees, there is a slightly different infinitary λ-calculus (called 001-infinitary) where $M \longrightarrow_{\beta\bot}^{\infty} \mathrm{BT}(M)$ for all $M$ (see the seminal paper by Kennaway et al., or Cerda and Vaux Auclair 2022 for a coinductive presentation).
The main benefit here is to extend the benefits of Böhm trees: give an account of the computational behavior of terms that do not normalize. In very vague words: once you excluded some meaningless programs (like $\Omega$), you obtain programs that do not necessarily terminate but still compute something, and have a meaning (like $Y$). Think of a program computing the decimals of $\pi$: it is not terminating but it has a “limit output”, namely $\pi$.
(About this notion of meaning, Barendregt writes: “It is proposed that [the unsolvable] terms represent the notion of undefined. [...] This class should be considered as the meaningless terms.”)