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Here is a plausible generalization of Jordan curve theorem which I couldn't find a rigorous proof for it.

Let $K$ be a compact subset of $\mathbb{R}^2$ which is homotopic equivalent to $S^1.$ Prove that $\mathbb{R}^2-K$ has two connected components, one is bounded while the other is not.

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This is true for $\mathbb R^2$, but not for dimensions 3-and-higher; the general issue is dealt with by Schoenflies. See:

http://en.wikipedia.org/wiki/Schoenflies_problem

This is related (maybe equivalent) to the fact that there are no knots in $\mathbb R$ nor in $\mathbb R^2$

gary
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    But Alexander's Horned Sphere is not a counterexample to the question here. It is a counterexample to the statement that $\mathbb{R}^2\setminus K$ is has two simply connected components. – George Lowther Jun 26 '11 at 17:09
  • Right, my bad. I will edit it out. – gary Jun 26 '11 at 17:55