The mechanical way: we enumerate sets $\{a,b,c,d\}$ such that $a+b+c+d = 6$ and $a \ge b \ge c \ge d \in \{0, 1, 2, 3, 4\}$. These are:
$$\{4,2,0,0\}, \{4,1,1,0\}, \{3,3,0,0\}, \{3,2,1,0\}, \{3,1,1,1\}, \{2,2,2,0\}, \{2,2,1,1\}.$$ These represent the distinct ways to pick exponents in the expansion that will add up to exactly $6$. The next step is to compute the product of the coefficients of these terms, and then compute the number of times these products appear in the expansion.
For $\{4,2,0,0\}$, this corresponds to the product $(5)(3)(1)(1) = 15$, and there are $\frac{4!}{1!1!2!} = 12$ ways to pick these powers in the expansion, for a contribution of $12(15) = 180$.
For $\{4,1,1,0\}$, this corresponds to the product $(5)(-2)(-2)(1) = 20$, and there are $\frac{4!}{1!2!1!} = 12$ ways to pick these powers in the expansion, for a contribution of $240$.
These and the remaining partitions are summarized as follows:
$$\begin{array}{c|c|c|c}
\text{Partition} & \text{Coefficients} & \text{Combinations} & \text{Total} \\
\hline
\{4,2,0,0\} & (5)(3)(1)(1) = 15 & \frac{4!}{1!1!2!} = 12 & 180 \\
\{4,1,1,0\} & (5)(-2)(-2)(1) = 20 & \frac{4!}{1!2!1!} = 12 & 240 \\
\{3,3,0,0\} & (-4)(-4)(1)(1) = 16 & \frac{4!}{2!2!} = 6 & 96 \\
\{3,2,1,0\} & (-4)(3)(-2)(1) = 24 & \frac{4!}{1!1!1!1!} = 24 & 576 \\
\{3,1,1,1\} & (-4)(-2)(-2)(-2) = 32 & \frac{4!}{1!3!} = 4 & 128 \\
\{2,2,2,0\} & (3)(3)(3)(1) = 27 & \frac{4!}{3!1!} = 4 & 108 \\
\{2,2,1,1\} & (3)(3)(2)(2) = 36 & \frac{4!}{2!2!} = 6 & 216 \\
\hline
& & & 1544
\end{array}$$
So the coefficient of $x^6$ is $1544$.