Let $m_2(\Omega)$ denote the 2-dimensional Lebesgue measure of $\Omega$, which is just its area. First let's check when $X,Y$ are independent, in which case they are also uncorrelated. Take any $(x_0,y_0) \in \Omega$, then $$f_X(x_0) = \int_{-\infty }^{\infty }f_{XY}(x_0,y)dy=\frac{m_1((x=x_0)\cap\Omega)}{m_2(\Omega)}$$
$$f_Y(y_0) = \int_{-\infty }^{\infty }f_{XY}(x,y_0)dx=\frac{m_1((y=y_0)\cap\Omega)}{m_2(\Omega)}$$
Then $X,Y$ are independent iff for all $(x_0,y_0)\in \Omega$, $$\frac{m_1((x=x_0)\cap\Omega)\cdot m_1((y=y_0)\cap\Omega)}{m_2(\Omega)^2}=f_X(x_0)f_Y(y_0) =f_{XY}(x_0,y_0)=\frac1{m_2(\Omega)}$$
$$\iff m_1((x=x_0)\cap\Omega)\cdot m_1((y=y_0)\cap\Omega)=m_2(\Omega)$$
This means $m_1((x=x_0)\cap\Omega)\cdot m_1((y=y_0)\cap\Omega)$ is constant, certainly a rectangle satisfies this requirement. You say $\Omega$ is a bounded region on $\mathbb R^2$, and I take that to mean a bounded open connected subset. So the question is whether there exists a bounded open connected subset $\Omega$ of $\mathbb R^2$ which is not a rectangle, such that $m_1((x=x_0)\cap\Omega)\cdot m_1((y=y_0)\cap\Omega)$ is constant for all $(x_0,y_0) \in \Omega$.
I'm not very good at geometry but intuitively I think it's impossible. Since $\Omega$ is bounded, $y_0$ is also bounded, which means that as $x_0$ moves along the $x$-axis, the measure of $y_0$'s such that $(x_0,y_0)\in\Omega$, or $m_1((x=x_0)\cap\Omega)$(does this have a name in geometry?), changes abruptly from $0$ to some positive number (otherwise $m_1((y=y_0)\cap\Omega)\to\infty$ and $x_0$ is unbounded). And I can imagine this scenario only when $\Omega$ is a rectangle. Perhaps someone else good at geometry can help me finish my argument.