Observables are self-adjoint elements of a $C^*$algebra. As such, this structure seems sufficient to describe physics.
A theorem by Gelfand and Naimark says that a $C^*$algebra can always be faithfully represented as bounded operators on a Hilbert space, $B(H)$. Then one can introduces different topologies, and one can see von Neumann algebra as a $C^*$subalgebra of $B(H)$ that is moreover complete in one of those topologies.
In another question of Physics stack exchange https://physics.stackexchange.com/q/2043/2451 someone also talks about the Borel functional calculus, and one also compare von Neumann algebra to "non commutative" measure theory vs "non commutative" for $C^*$algebras.
My question is, is the introduction of von Neumann algebra only a technical thing or has it physical consequences? Or maybe more precisely, why is it important to consider several topologies on our algebra of operators?
ps: I posted the exact same question in physics, but it may be more relevant in math.