In how many ways $P,Q,R,S,T,U$ can be arranged such that $ P, Q$ should come before $T,U$ ?
Do we have to find the ways that $P$ and $Q$ can be placed in the first four position?
In how many ways $P,Q,R,S,T,U$ can be arranged such that $ P, Q$ should come before $T,U$ ?
Do we have to find the ways that $P$ and $Q$ can be placed in the first four position?
We interpret the question as asking for the number of ways to arrange the letters so that $P$ is before $T$ and $U$, and also $Q$ is before $T$ and $U$.
Consider just the $4$ letters $P,Q,T,U$. There are $(2)(2)$ ways to arrange them so that our condition is fulfilled. And there are $4!$ ways to arrange them with no restriction.
Thus the probability that our arrangement of $6$ letters satisfies the condition is $\frac{4}{4!}$. There are $6!$ equally likely arrangements, so the required number of arrangements is $6!\cdot\frac{4}{4!}$.
Remark: We used a probabilistic argument. However, we can use pure counting. The positions to be occupied by our $4$ important letters can be chosen in $\binom{6}{4}$ ways. By our argument above, the actual locations of $P,Q,T,U$ can be chosen in $(2)(2)$ ways. Then the remaining $2$ letters can be put in the two open solots in $2!$ ways, for a total of $\binom{6}{4}(2)(2)(2!)$.