I'm trying to solve this box-proof puzzle but I don't understand how to complete it as I need to somehow assume $A0$ or $\neg\neg B2$.

I've used a truth-table solver to confirm that this is a tautology so it must be solvable using box proofs:
$$(\neg\neg C\to C)\to ((\neg\neg D\to D)\to ((\neg\neg E\to E)\to (((A\to C)\to D)\to (((A\to C)\to C)\to D)\to (((B\to D)\to E)\to ((((B\to C)\to D)\to E)\to E)))))$$