Loosely speaking, category theory suggests that "equivalence relation" is dual to "subset." Anyway, since axioms correspond to subclasses of the possible models of a signature, is there some notion of "coaxiom" that corresponds to making "equivalent" (that is, isomorphic) previously non-equivalent models?
For example, it would be cool if by adding coaxioms to the notion of a metric space, we could obtain the notion of "metric space up to uniform scaling of distances." Similarly, it would be cool if by adding coaxioms to the notion of a topological space, we could obtain the notion of "topological space up to homotopy equivalence."