It appears to me at first glance that your idea, as a proof strategy, is fundamentally well founded but might be difficult to execute directly. I think it might be simpler to show that $DF$, the Jacobean of $F$, is singular at $(2, 1)$ in a straightforward manner, as follows:
Let us denote the components of $F:\Bbb R^2 \to \Bbb R^2$ by $F_x$ and $F_y$, so that $F(x, y) = (F_x(x, y), F_y(x, y))$ for $(x, y) \in \Bbb R^2$. Consider the curve $\gamma(t) = (3t^3 + 2, e^{t^2})$ in $\Bbb R^2$. Clearly $\gamma(0) = (2, 1)$, so $\gamma(t)$ passes through the point $(2, 1) \in \Bbb R^2$ when $t = 0$. We are given that $F(3t^3 + 2, e^{t^2}) = (3, 6)$ for all $t \in \Bbb R$; writing it out in terms of components yields
$F_x(3t^3 + 2, e^{t^2}) = 3, \tag{1}$
and
$F_y(3t^3 + 2, e^{t^2}) = 6. \tag{2}$
If we now differentiate (1) and (2) with respect to $t$ using the chain rule, we obtain
$(\partial F_x / \partial x)(3t^3 + 2, e^{t^2})(9t^2) + (\partial F_x / \partial y)(3t^3 + 2, e^{t^2})(2te^{t^2}) = 0 \tag{3}$
and
$(\partial F_y / \partial x)(3t^3 + 2, e^{t^2})(9t^2) + (\partial F_y / \partial y)(3t^3 + 2, e^{t^2})(2te^{t^2}) = 0 \tag{4}$
holding for any $t \in \Bbb R$. We can re-write (3), (4) as the matrix-vector equation
$\begin{bmatrix} \partial F_x / \partial x & \partial F_x / \partial y \\ \partial F_y / \partial x & \partial F_y / \partial y \end{bmatrix}_{(3t^3 + 2, \; e^{t^2})} \begin{pmatrix} 9t^2 \\ 2te^{t^2} \end{pmatrix} = 0, \tag{5}$
which indicates the Jacobean of $F$ is singular for any $t \ne 0$, since the vector $(9t^2, 2te^{t^2})^T \ne 0$ for $t \ne 0$. This implies that
$\det(\begin{bmatrix} \partial F_x / \partial x & \partial F_x / \partial y \\ \partial F_y / \partial x & \partial F_y / \partial y \end{bmatrix}_{(3t^3 + 2, \; e^{t^2})}) = 0 \tag{6}$
for any point on the curve $\gamma(t)$ where $t \ne 0$; since the determinant of a square matrix is a continuous function of its entries, letting $t \to 0$ shows
$\det(DF(2, 1)) = \det(\begin{bmatrix} \partial F_x / \partial x & \partial F_x / \partial y \\ \partial F_y / \partial x & \partial F_y / \partial y \end{bmatrix}_{(2, \; 1)}) = 0, \tag{7}$
whence $DF(2, 1)$ is not invertible. QED.
From the other point of view, $F$ is clearly not injective in any neighborhood of $(2, 1)$ since it maps the entire curve $\gamma(t)$ to the single point $(3, 6)$. And as Professor Shifrin points out in his answer, there is an entire interval $I = (-\epsilon, \epsilon)$, $\epsilon > 0$, with $\gamma(I) \subset U$.
Hope this helps. Cheerio,
and as always,
Fiat Lux!!!