Doron Zeilberger posted a question here: http://arxiv.org/abs/1401.1532 of evaluating the determinant of a very sparse matrix. The $2d \times 2d$ matrix $M(d)$ has ones in the pattern $1,0,1,0,1,0,\dots$ in both the subdiagonals and the superdiagonals. And $M_{b-1,2b}=M_{3b+1,2b-1}=-1$, for all $b$. The entries are zero everywhere else.
This matrix happens to be related to the Collatz Conjecture, in that the matrix is nonsingular for all $d$ iff there are no nontrivial cycles of the Collatz function iteration. See http://www.math.rutgers.edu/~zeilberg/mamarim/mamarimhtml/detconj.html
If one swaps all odd and even columns, $2b-1$ and $2b$, one gets all ones on the diagonal of this matrix. Then if one performs Gaussian elimination, one gets an upper-triangular matrix with all ones on the diagonal (for any $d$); therefore, the matrix is nonsingular. I verified this on a spreadsheet.
If this doesn't convince you, here is a formal proof:
(Invalid formal proof)
We'll prove the conjecture that $\det M(d)=(−1)^d$, via induction on $d$. It's trivial to check for $d=1,2$.
We'll assume true for $d=k$ and prove true for $d=k+1$. We'll use Laplace expansion (by cofactors) along column $2d−1$ to prove that the $\det M(d)=(−1)^d$. Notice that this column has only one nonzero entry in the last row, namely 1; therefore, $\det M(d)=(−1)^{2d+(2d−1)}M_{2d,2d−1}=−M_{2d,2d−1}$.
Suppose $d$ is odd. Then to evaluate $M_{2d,2d−1}$, we use Laplace expansion along row $2d−1$. Then $M_{2d,2d−1}=(−1)^{(2d−1)+(2d−1)}\det M(d−1)=\det M(d−1)$, since the only nonzero entry is in column $2d$, which is 1. Hence, $\det M(d)=−M_{2d,2d−1}=−\det M(d−1)=(−1)^d$, by the induction hypothesis.
Suppose $d$ is even. Then to evaluate $M_{2d,2d−1}$, again we use Laplace expansion along row $2d−1$. There are two nonzero entries in this row, namely the one in column $2d$, which is 1, and the one in column $d+1$, which is -1. Then we get $M_{2d,2d−1}=(−1)^{(2d−1)+(2d−1)}M(d−1)+(−1)^{(2d−1)+(d+1)}\cdot (−1)\cdot 0=\det M(d−1)$. The last term is zero, because row $d+2$ has all zeroes when column $d+1$ is deleted. Hence, $\det M(d)=−M_{2d,2d−1}=−\det M(d−1)=(−1)^d$, by the induction hypothesis. QED
What am I missing here? This was way too easy.