Your idea is good, but the calculations are all wrong.
$$
F_X(x) = P\{X \leq x\} = P\{5Z_1-Z_2 \leq x\}
= \int_{z_1 = -\infty}^\infty \int_{z_2 = 5z_1-x}^\infty f_{1,2}(z_1,z_2)
\,\mathrm dz_2 \,\mathrm dz_1\\
$$
If you differentiate $F_X(x)$ with respect to $x$ to get the density
function $f_X(x)$, you will find that
$$\begin{align}f_X(x) &= \frac{\partial F_X(x)}{\partial x}\\
&=\frac{\partial}{\partial x} \int_{z_1 = -\infty}^\infty\left[ \int_{z_2 = 5z_1-x}^\infty f_{1,2}(z_1,z_2)
\,\mathrm dz_2\right] \,\mathrm dz_1\\
&= \int_{z_1 = -\infty}^\infty\left[ \frac{\partial}{\partial x}
\int_{z_2 = 5z_1-x}^\infty f_{1,2}(z_1,z_2)
\,\mathrm dz_2\right] \,\mathrm dz_1\\
&= \int_{-\infty}^\infty f_{1,2}(z_1,5z_1-x)\,\mathrm dz_1.
\end{align}$$
At this point, if you want, you can use the independence of
$Z_1$ and $Z_2$ to express $f_{1,2}(z_1, 5z_1-x)$ as
$f_1(z_1)f_2(5z_1-x)$ and proceed to calculate the
density of $X$ in more detail.
For the special case when $Z_1$ and $Z_2$ are independent normal random
variables, then you can use the facts that
to write down the density of $X$ without doing any integration.