A literal consists of a lower case letter or its negation. Each conjunction here consists of three literals from the set of literals {p, ¬p, q, ¬q, r, ¬r} where no letter appears twice in a conjunction. Now, suppose that we have a conjunction with ¬p as the first literal. What are the other possibilities for the other two literals? Well, the possibilities correspond to pairs (q, r), (q, ¬r), (¬q, r), (¬q, ¬r). Consequently, every possibility for "¬p" gets covered by the last four conjunctions cover all cases where "¬p" holds true. Thus, if any of the last 4 cases, then ¬p holds true.
Perhaps a better way to think about it, let's write the truth table out here:
p q r F(p, q, r)
0 0 0 1
0 0 1 1
0 1 0 1
0 1 1 1
1 0 0 0
1 0 1 0
1 1 0 1
1 1 1 0
If p, q, and r are false, then ¬p, ¬q, and ¬r are true. Thus (¬p$\land$¬q$\land$¬r) corresponds to the first row above. (¬p$\land$¬q$\land$r) corresponds to the second row above and so. The last four conjunctions of the formula in the post correspond to the 1st 4 rows above. This consists of the only time that ¬p holds true. Equivalently, if ¬p holds true, then a disjunction of the 4 conjunctions will hold true. Consequently, we can replace such a disjunction of conjunctions by ¬p.
Actually, we could further simplify the formula to [¬p$\lor$(q$\land$$\lnot$r)].