Let $H$ be a Hilbert space and $F :H \to \mathbb R$. Suppose that $F$ is Gâteaux differentiable at $u \in H$, then gradient of $F$ at $u$, denoted by $\text{grad}F(u)$, is given by the unique $w \in H$ which satisfies
$$\langle F'(u), v \rangle_H = \langle w, v \rangle_H \quad \forall v \in H.$$
When we restrict $v$ to some set $X \subset H$, we have the so-called constraint gradient. Then we usually write $\text{grad}_H^X F(u)$ to denote the unique element of the following set
$$\left\{ f \in H : \quad \lim_{t \to 0} \frac 1t \big( F(u+tv) - F(u) \big) = \langle f, v \rangle_H \quad \forall v \in X\right\}$$
least norm. Hence, for each $X$ and $H$, we have certain flows which mainly depend on how we calculate $\text{grad}_H^X F(u)$.
For example, let say
$$F(u) = \frac 12 \int_\Omega |du|^2 dx.$$
Clearly, with $X = C_0^\infty (\Omega)$, we have
$$\text{grad}_{L^2}^X F(u) = -\Delta u$$
while we have
$$\text{grad}_{H^1}^X F(u) = u$$
and
$$\text{grad}_{H^{-1}}^X F(u) = \Delta^2 u.$$
In other words, the equation
$$u_t = -\Delta u$$
will be a $L^2$-gradient flow associated to the energy functional $F$ above. However, it is no longer the $H^{-1}$-gradient flow associated to the energy functional $F$ but the following equation
$$u_t = \Delta^2 u.$$