You can differentiate RHS as the following :
$$\begin{align}\frac{d}{dx}(2\sqrt y\ (x+y^2))&=\left(\frac{d}{dx}(2\sqrt y)\right)(x+y^2)+2\sqrt y\left(\frac{d}{dx}(x+y^2)\right)\\&=\left(\frac{d(2\sqrt y)}{dy}\cdot\frac{dy}{dx}\right)(x+y^2)+2\sqrt y\ \left(1+\frac{d(y^2)}{dy}\cdot\frac{dy}{dx}\right)\\&=\left(\frac{1}{\sqrt y}\cdot y'\right)(x+y^2)+2\sqrt y\ (1+2yy').\end{align}$$
So, since you'll have
$$\frac{5}{2\sqrt x}=\left(\frac{1}{\sqrt y}\cdot y'\right)(x+y^2)+2\sqrt y\ (1+2yy'),$$
you'll have the following to solove for $y'$ :
$$\frac{5}{2\sqrt 4}=\left(\frac{1}{\sqrt 1}\cdot y'\right)(4+1^2)+2\sqrt 1\ (1+2\cdot 1\cdot y').$$
The answer will be $y-1=y'(x-4)$.