The question comes from Exercise 1.1.2 of the book "An Invitation to Algebraic Geometry". By definition the unitary group U(n) is the group of all complex matrix that satisfies $U^*U=I$. I know that since conjugate is involved the definition equations are not complex polynomials.
But this doesn't answer the question. To answer the question we have to prove that "there does not exist a set of polynomials whose common zero set is U(n)".
For odd n I have an idea: since the real dimension of U(n) is $n^2$, when n is odd it cannot be a complex variety whose real dimension should always be even(am I right here?). But what if n is even? Any hints will be appreciated.
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I think I've got the idea of @orangeskid answer. Let me edit the post and make it more detailed, so that others can understand.
First let's state 3 lemmas:
Lemma 1. Given an analytic function $f$ on $\mathbb{C}^n$, and suppose $W$ is a $n$ (real) dimensional linear subspace of $\mathbb{C}^n$ such that $\mathbb{C}^n\cong W+iW$, if $\left.f\right |_W\equiv 0$, then $f\equiv 0$.
Lemma 2. The Lie algebra $W=u(n)\subset \mathbb{C}^{n^2}$ of the Lie group $U(n)\subset GL(n,\mathbb{C})$ has a real dimension of $n^2$, and has the property that $\mathbb{C}^{n^2}\cong W+iW$.
Lemma 3. Given an analytic function $g: GL(n,\mathbb{C})\rightarrow \mathbb{C}$ that vanishes on $U(n)$, the exponential map exp transplants it to an analytic function $f=g\circ \exp: \mathbb{C}^{n^2}\rightarrow \mathbb{C}$ that vanishes on $u(n)$.
Once we have the 3 lemmas, it's easy: Suppose $g: \mathbb{C}^{n^2}\rightarrow \mathbb{C}$ is a polynomial vanishing on $U(n)$. Based on Lemma 3 we get an analytic function $f=g\circ \exp: \mathbb{C}^{n^2}\rightarrow \mathbb{C}$ vanishing on $u(n)$, so according to Lemma 1 and 2 we have $f\equiv 0$, which implies $g\equiv0$ on $\exp(\mathbb{C}^{n^2})=GL(n,\mathbb{C})$. Q.E.D.
So we need only to prove the lemmas.
Proof of Lemma 1:
Identifying $\mathbb{C}^n$ as $\mathbb{R}^{2n}$, choose an orthonormal basis $\{e_1, e_2, \dots, e_n \}$ of $W$. Then $\{e_1, \operatorname{J}(e_1), \dots, e_n, \operatorname{J}(e_n)\}$ is an orthonormal basis of $\mathbb{R}^{2n}$, where $\operatorname{J}$ is the almost complex structure of $\mathbb{C}^n$. Do a coordinate transformation so that these basis become the (real)coordinate basis of the coordinate $\{z_1, \dots, z_n\}=\{x^1+iy^1, \dots, x^n+iy^n\}$ and the conclusion reduces to the following one:
If the analytic function $f: \mathbb{C}^n \rightarrow \mathbb{C}$ vanishes on the real coordinates, that is, $f(x^1, \dots, x^n)\equiv 0$, then $f(z_1, \dots, z_n)\equiv 0$.
$\forall x^2, \dots, x^n$, let $g(z)=f(z, x^2, \dots, x^n)$, $g$ is analytic and $g(x)=f(x, x^2, \dots, x^n)\equiv 0, \forall x\in \mathbb{R}$. So $g\equiv 0$, that is, $f(z_1, x^2, \dots, x^n)\equiv 0, \forall z_1\in\mathbb{C}, x^i\in\mathbb{R}, i=2, \dots, n$. Continue the process we'll get $f(z_1, z_2, \dots, z_n)\equiv 0$. Q.E.D.
Proof of Lemma 2:
$u(n)$ is the group of all n × n skew-Hermitian matrices, having a real dimension of $n^2$. For any n × n complex matrix A, Write A as $$A=\frac{A-A^*}{2} + i\cdot(-i)\frac{A+A^*}{2}$$. Q.E.D.
Proof of Lemma 3:
This is trivial since exp is analytic. Q.E.D.