Here is an explanation in words rather than logical symbols:
The negation of "for every/for all" ($\forall$) is "there exits" ($\exists$).
Example: The negation of the statement "$\forall x, p(x)$" is "$\exists x$, ~$p(x)$" (~ stands for "not").
The negation of "there exists" ($\exists$) is "for every/for all" ($\forall$).
Example: The negation of the statement "$\exists x$ such that $p(x)$" is "$\forall x$, ~$p(x)$".
The negation of "if $p$, then $q$" is "$p$ and ~$q$" (note: the negation of an "if, then" statement is NOT an "if, then" statement).
Example: The negation of the statement "if $p(x)$, then $q(x)$" is "$p(x)$ and not $q(x)$".
The negation of "$p$ or $q$" is "~$p$ and ~$q$".
The negation of "$p$ and $q$" is "~$p$ or ~$q$".
Now, we need to negate $\forall x$ $\exists y$ $\forall z$ ($P(x) \land$ ~$Q(x)$) $\implies (R(x) \lor (R(y) \land $ ~$Q(z)$).
You need to start negating from left to right, just as if you were reading. The first three negations are easy. $\forall x$ $\exists y$ $\forall z$ becomes $\exists x$ $\forall y$ $\exists z$.
Now, the next largest statement if the "if, then" statement. Using the rules above, we know that the negation of $p \implies q$ is $p \land $ ~$q$. So, applying this to the implication gives that ($P(x) \land$ ~$Q(x)$) $\implies (R(x) \lor (R(y) \land $ ~$Q(z)$) becomes ($P(x) \land$ ~$Q(x)$) $\land$ ~$ [(R(x) \lor (R(y) \land $ ~$Q(z)$)].
Now, we see that we need to negate $(R(x) \lor (R(y) \land $ ~$Q(z)$). The outer statement is an "or" statement, and so using the rules above, its negation is ~$R(x) \land$ ~$(R(y) \land $ ~$Q(z)$).
Finally, we need to negate the "and" statement $R(y) \land $ ~$Q(z)$. But using the rules above, the negation becomes ~$R(y) \lor Q(z)$.
So, putting it all together, the negation of $\forall x$ $\exists y$ $\forall z$ ($P(x) \land$ ~$Q(x)$) $\implies (R(x) \lor (R(y) \land $ ~$Q(z)$) is:
$\exists x$ $\forall y$ $\exists z$ ($P(x) \land$ ~$Q(x)$) $\land$ (~$R(x) \land$ (~$R(y) \lor Q(z)$)).