As the OP says, in 3 dimensions you find the plane normal of a plane spanned by two vectors by the cross product.
So, the hope is that in N dimensions you can find the normal of a hyperplane spanned by N-1 vectors by some sort of generalized cross product.
I just tried generalizing the cross product by heuristic induction. In 3 dimensions, I know from textbooks that the $i$th component of the cross product can be written as
$$crossproduct_{3dim}(a,b)_i=(a \times b)_i=\sum_{j=1..3, k=1..3} \epsilon_{ijk} a_j b_k$$
with $\epsilon_{ijk}$ the so-called Levi-Civita symbol:
$$\epsilon_{ijk}=\left\{ \begin{array}{rl} 1 & \textrm{if $ijk$ is an even permuation of(1,2,3)}\\-1 & \textrm{if $ijk$ is an odd permuation of(1,2,3)}\\0&\textrm{otherwise} \end{array} \right.$$
The Levi-Civita symbol also exists in N dimensions (see Wikipedia. It has as many subscripts as the space has dimensions). So, straight-forward, we have in 2 dimensions:
$$ crossproduct_{2dim}(a)_i = \epsilon_{ij} a_j = (a_2, -a_1)$$
The far right-hand side is what we expect: It is orthogonal to $(a_1, a_2)$ - check!
We have not written down the summation sign over $j$ for brevity, but summation is assumed.
Alas, it should also work in 4 dimensions:
$$ crossproduct_{4dim}(a,b,c)_i = \epsilon_{ijkl} a_j b_k c_l$$
Again, summation over j, k, and l is assumed.
For lack of analytical skills, we verify experimentally using random inputs $a, b$, and $c$, with a digital computing machine:
$$a=(-0.499992, -0.368462, 0.255605 ,-0.0413499)\\ b=(0.0327672, -0.281041 ,-0.452955, 0.178865)\\ c= (0.179296, 0.434693, -0.116498, 0.0194164)\\
d = crossproduct_{4dim}(a,b,c) = (0.0073357, 0.00118694, 0.0273487, 0.0697787)$$
Verifying orthogonality using the dot product:
$$a\cdot d = -4.33681 \times 10^{-19}\\
b\cdot d = 1.73472\times 10^{-18}\\
c\cdot d = 6.50521\times 10^{-19}
$$
These numbers are equal to zero within the numeric uncertainty. Assumption "proven". $\square$
PS: Anyone confirming this works in all cases and/or this is equivalent to one/all of the previous answers?