I would say "Always except when the first number is an integer and the second number is a fraction":
- $\frac 34 6 = \frac 34\cdot 6 = \frac 92$ just multiplication.
- $5(7-3) = 5\cdot(7-3)=20$ just multiplication.
- $6\frac 34$ could either be $6+\frac34$ or $6\cdot\frac34$ depending on context.
The "mixed fraction" notation ($6\frac34=6+\frac34$) is more common in "everyday life" (e.g. when buying pie, a sign may say "$2\frac12$ pie for only $10$ dollars") whereas "implicit multiplication" notation ($6\frac34=6\cdot\frac34$) is more common in mathematical contexts.
In my opinion, when you write $6\frac34$ and you want it to mean $6\cdot\frac34$, one should just write the dot there to avoid confusion. If you want it to mean $6+\frac34$, make sure you are not in a mathematical context. If you are, write a $+$ there, or write it as $\frac{27}4$.